2-Fluorobenzyl bromide
2-fluorobenzyl bromide
CAS: 446-48-0
Molecular Formula: C7H7FO
2-Fluorobenzyl bromide - Names and Identifiers
| Name | 2-fluorobenzyl bromide |
| Synonyms | 2-Fluorobenzylbromide 2-fluorobenzyl bromide α-Bromo-2-fluorotoluene à-bromo-2-fluorotoluene ALPHA-BROMO-O-FLUOROTOLUENE 2-fluoro(bromomethyl)benzene |
| CAS | 446-48-0 |
| EINECS | 207-169-1 |
| InChI | InChI=1/C7H7FO/c8-7-4-2-1-3-6(7)5-9/h1-4,9H,5H2 |
2-Fluorobenzyl bromide - Physico-chemical Properties
| Molecular Formula | C7H7FO |
| Molar Mass | 126.128 |
| Density | 1.173g/cm3 |
| Boling Point | 196.1°C at 760 mmHg |
| Flash Point | 90.6°C |
| Vapor Presure | 0.252mmHg at 25°C |
| Refractive Index | 1.52 |
| Physical and Chemical Properties | Colorless liquid with chemical properties |
| Use | Use 2-fluorobenzyl bromide as an organic intermediate. |
2-Fluorobenzyl bromide - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 |
2-Fluorobenzyl bromide - Upstream Downstream Industry
2-Fluorobenzyl bromide - Preparation
method 1.
2-fluorotoluene, N-bromosuccinimide, dibenzoyl peroxide and chloroform are mixed evenly, argon gas is introduced, the pressure is controlled to 2 atmospheres, the temperature is controlled to 100 ℃, and the stirring reaction is finished after 1.5h to obtain a mixture containing 2-fluorobromobenzyl.
Method 2.
At 0°C, CBr4(31.6g,95.2mmol) was added in small batches to the DCM solution of (2-fluorophenyl) methanol (Aldrich,10.0g,79.3mmol) and triphenylphosphine (29.1g,111mmol). Stir the mixture at room temperature for 2h. The solvent was evaporated and the residue was purified by rapid chromatography (cyclohexane: ethyl acetate 95 ∶ 5) to give 2-fluorobenzyl (14g,93%).
Last Update：2024-04-10 22:29:15
2-Fluorobenzyl bromide - Nature
| storage conditions | Inert atmosphere,2-8°C |
| morphology | Liquid |
| color | Clear colorless to slightly yellow |
| Specific gravity | 1.567 |
| sensitivity | Lachrymatory |
| BRN | 1099894 |
| InChIKey | FFWQLZFIMNTUCZ-UHFFFAOYSA-N |
| NIST chemical information | 2-Fluorobenzyl bromide(446-48-0) |
Last Update：2024-04-09 19:04:55
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View History
Downstream Products for 2-Fluorobenzyl bromide
ETHYL 2-FLUOROPHENYLACETATE
(2-FLUORO-PHENYL)-METHANESULFONYL CHLORIDE
2-BROMOMETHYL-1-FLUORO-4-NITROBENZENE
Cyclopropyl 2-fluorobenzyl ketone
2-FLUORO-DL-PHENYLALANINE
(2-FLUORO-BENZYL)-HYDRAZINE
(2-FLUORO-PHENYL)-METHANESULFONYL CHLORIDE
2-BROMOMETHYL-1-FLUORO-4-NITROBENZENE
Cyclopropyl 2-fluorobenzyl ketone
2-FLUORO-DL-PHENYLALANINE
(2-FLUORO-BENZYL)-HYDRAZINE